Open up the preferences for your checkbox and select the Actions tab, then select to execute a JavaScript on Mouse-Up. Use something like this to reset the form fields, and make them read-only or read-write. Just keep in mind that you need to use the names of your dropdown fields, and not the names I am using:
if (event.target.value == "Yes")
{
this.resetForm( [ "Dropdown1", "Dropdown2" ] );
this.getField("Dropdown1").readonly = true;
this.getField("Dropdown2").readonly = true;
}
else
{
this.getField("Dropdown1").readonly = false;
this.getField("Dropdown2").readonly = false;
}