Every time the mouse hovered over a pdf file, two AcroRd instances were created. They don't go away by themselves, hogging memory and silently paralyzing the machine. Sometimes, it threw a series of "Acrobat failed to connect to a DDE server" errors.
The solution was to disable/unregister the pdfshell:
regsvr32 "%CommonProgramFiles%\Adobe\Acrobat\ActiveX\pdfshell.dll" /u
This crazy problem apparently drove lots of folks to switch to Foxit.