Regardless of the "tool" used it is good to know/understand that PDF is not a file format intended to support the sort of edit / format / layout changes you can do with word processing (Word Perfect, Word, FrameMaker, InDesign, Open Office, etc.).
You are able to do minor touchups. More than that can result in a goobered PDF.
If a series of minor edits are to be done it helps to do incremental save as to make a string of PDFs (file01.pdf, file02.pdf, etc.) so that all work is not lost if an "oops" happens.
See: ISO-320001
http://wwwimages.adobe.com/www.adobe.com/content/dam/Adobe/en/devnet/pdf/pdfs/P
DF32000_2008.pdf
Be well....